Paullinia pinnata herb review and benefit, free radical scavenger

Paullinia pinnata is an African woody vine widely used in traditional medicine for the treatment of malaria. This herb has antioxidant benefits.

Antioxidant properties of the methanol extracts from the leaves of Paullinia pinnata.
J Med Food. 2007 December. Jimoh FO, Sofidiya MO, Afolayan AJ. Jimoh FO, Sofidiya MO, Afolayan AJ. Department of Botany, University of Fort Hare, Alice, South Africa.
The in vitro antioxidant activities of the methanol extract of paullinia pinnata leaves were evaluated using different testing systems. The results showed that Paullinia pinnata possessed strong scavenging activity and moderate reducing power. The total phenol, flavonoid, and proanthocyanidin contents of the extracts were very close to those reported for most medicinal plants and showed good correlation with its antioxidant activities. These properties are probably part of the reasons why Paullinia pinnata is effective in folk medicine.

Paullinia pinnata research studies
Paullinia pinnata extracts rich in polyphenols promote vascular relaxation via endothelium-dependent mechanisms.
J Cardiovasc Pharmacol. 2006 April Zamble A, Carpentier M, Kandoussi A, Sahpaz S, Petrault O, Ouk T, Hennuyer N, Fruchart JC, Staels B, Bordet R, Duriez P, Bailleul F, Martin-Nizard F. Laboratoire de Pharmacognosie, Faculté de Pharmacie, Université de Lille 2, Lille, France.
Paullinia pinnata L. (Sapindaceae) is an African tropical plant whose roots and leaves are used in traditional medicine for many purposes, especially for erectile dysfunction, but its action mechanism is unknown. Paullinia pinnata root and leaf methanolic extracts are rich in phenolic compounds. This study shows that both extracts are highly antioxidative and induce a slight transcriptional activity of peroxisome proliferator activated receptor-alpha. They also increased and decreased endothelial nitric oxide synthase and endothelin-1 mRNA levels in bovine aortic endothelial cells, respectively. In this study P. pinnata methanolic extracts in cumulative doses elicited in a dose-dependent manner the relaxation of phenylephrine precontracted isolated rat aortic rings. N-nitro-L-arginine methyl ester significantly attenuated the capacity of both extracts to induce arterial relaxation, indicating that this arterial relaxation was mediated by endothelial nitric oxide release. It could be suggested that the arterial relaxation induced by both extracts could be mainly linked to their capacities to inhibit nitric oxide oxidation through their antioxidant properties.

Paulina species
Paullinia crysan
Paullinia cupana herb
Paulinia pinnata herb
Paullinia sorbilis

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