Paullinia pinnata herb review and
benefit, free radical scavenger
Paullinia pinnata is an African woody vine widely used in traditional medicine
for the treatment of malaria. This herb has
antioxidant benefits.
Antioxidant properties of the
methanol extracts from the leaves of Paullinia pinnata.
J Med Food. 2007 December. Jimoh FO, Sofidiya MO, Afolayan AJ. Jimoh FO,
Sofidiya MO, Afolayan AJ. Department of Botany, University of Fort Hare, Alice,
South Africa.
The in vitro antioxidant activities of the methanol extract of paullinia pinnata
leaves were evaluated using different testing systems. The results showed that
Paullinia pinnata possessed strong scavenging activity and moderate reducing
power. The total phenol, flavonoid, and proanthocyanidin contents of the
extracts were very close to those reported for most medicinal plants and showed
good correlation with its antioxidant activities. These properties are probably
part of the reasons why Paullinia pinnata is effective in folk medicine.
Paullinia pinnata research studies
Paullinia pinnata extracts rich in polyphenols promote vascular relaxation
via endothelium-dependent mechanisms.
J Cardiovasc Pharmacol. 2006 April Zamble A, Carpentier M, Kandoussi A, Sahpaz
S, Petrault O, Ouk T, Hennuyer N, Fruchart JC, Staels B, Bordet R, Duriez P,
Bailleul F, Martin-Nizard F. Laboratoire de Pharmacognosie, Faculté de Pharmacie,
Université de Lille 2, Lille, France.
Paullinia pinnata L. (Sapindaceae) is an African tropical plant whose roots and
leaves are used in traditional medicine for many purposes, especially for
erectile dysfunction, but its action mechanism is unknown. Paullinia pinnata
root and leaf methanolic extracts are rich in phenolic compounds. This study
shows that both extracts are highly antioxidative and induce a slight
transcriptional activity of peroxisome proliferator activated receptor-alpha.
They also increased and decreased endothelial nitric oxide synthase and
endothelin-1 mRNA levels in bovine aortic endothelial cells, respectively. In
this study P. pinnata methanolic extracts in cumulative doses elicited in a
dose-dependent manner the relaxation of phenylephrine precontracted isolated rat
aortic rings. N-nitro-L-arginine methyl ester significantly attenuated the
capacity of both extracts to induce arterial relaxation, indicating that this
arterial relaxation was mediated by endothelial nitric oxide release. It could
be suggested that the arterial relaxation induced by both extracts could be
mainly linked to their capacities to inhibit nitric oxide oxidation through
their antioxidant properties.
Paulina species
Paullinia crysan
Paullinia
cupana herb
Paulinia pinnata herb
Paullinia sorbilis
Pill web site