Piper Longum, Pippali, Indian long pepper
Piper Longum has been used traditionally as a digestive aid, sexual stimulant, general tonic, and mucolytic.
Antiplatelet effects of acidamides isolated from the fruits of Piper longum
L.
Phytomedicine. 2007 December. Institute of Ecological Phytochemistry, Hankyong
National University, Ansung City, Kyonggi-Do 456-749, Republic of Korea.
The inhibitory effects of four acidamides, piperine, pipernonaline,
piperoctadecalidine, and piperlongumine, isolated from the fruits of Piper
longum L. on washed rabbit platelet aggregation were examined. All of the four
tested acidamides showed dose-dependent inhibitory activities on washed rabbit
platelet aggregation induced by collagen, arachidonic acid (AA), and
platelet-activating factor (PAF), except for that induced by thrombin.
Piperlongumine, in particular, showed stronger inhibitory effects than other
acidamides to rabbit platelet aggregation induced by collagen, AA and PAF.
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