Polygonatum sibiricum herb

Polygonatum sibiricum Redoute is a traditional Chinese medicine also used by healers in Mongolia.

Cardiotonic activity of the rhizome of Polygonatum sibiricum in rats.
Biol Pharm Bull. 1997 December. Hirai N, Miura T, Moriyasu M, Ichimaru M, Nishiyama Y, Ogura K, Kato A. Kobe Pharmaceutical University, Hyogo, Japan.
The cardiotonic effect of the rhizome of Polygonatum sibiricum was investigated in the left atria of rats. The methanol extract of the rhizome of Polygonatum sibiricum (1-7 mg/ml) concentration-dependently increased the developed tension of the left atrium. It also strongly inhibited cAMP phosphodiesterase. The increase cAMP level correlated the increase in left atrial contraction. On the other hand, Polygonatum sibiricum did not inhibit Na+, K+-ATPase. The cardiotonic effect of Polygonatum sibiricum was strongly inhibited by reserpine, a sympatholytic agent. Furthermore, OM-treated left atria inhibited the tension produced by propranolol, a beta adrenocepter antagonist. These findings suggested that the Polygonatum sibiricum cardiotonic effect is due to stimulating beta adrenoceptors through activation of sympathetic nerves.

Polygonatum sibiricum has steroidal saponins named neosibiricosides

The roots of Polygonatum sibiricum Redoute have alkaloids named polygonatine A and polygonatine B.

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