Polygonatum sibiricum herb traditional Chinese herbal medicine
Polygonatum sibiricum Redoute is a traditional Chinese medicine also used by healers in Mongolia.
Polygonatum sibiricum
herb research studies
Cardiotonic activity of the rhizome of Polygonatum
sibiricum in rats.
Biol Pharm Bull. 1997 December. Hirai N, Miura T, Moriyasu M, Ichimaru M,
Nishiyama Y, Ogura K, Kato A. Kobe Pharmaceutical University, Hyogo, Japan.
The cardiotonic effect of the rhizome of Polygonatum sibiricum was investigated
in the left atria of rats. The methanol extract of the rhizome of Polygonatum
sibiricum (1-7 mg/ml) concentration-dependently increased the developed tension
of the left atrium. It also strongly inhibited cAMP phosphodiesterase. The
increase cAMP level correlated the increase in left atrial contraction. On the
other hand, Polygonatum sibiricum did not inhibit Na+, K+-ATPase. The
cardiotonic effect of Polygonatum sibiricum was strongly inhibited by reserpine,
a sympatholytic agent. Furthermore, OM-treated left atria inhibited the tension
produced by propranolol, a beta adrenocepter antagonist. These findings
suggested that the Polygonatum sibiricum cardiotonic effect is due to
stimulating beta adrenoceptors through activation of sympathetic nerves.
Polygonatum sibiricum
herb chemistry
Polygonatum sibiricum has steroidal saponins named
neosibiricosides. The roots of Polygonatum sibiricum Redoute have
alkaloids named polygonatine A and polygonatine B. Polygonatum sibiricum also
has furostanol saponins, polygonoides A and B.
Pill web site