Puerarin

Puerarin is a major effective ingredient extracted from the traditional Chinese medicine Ge-gen (Radix Puerariae, RP). Puerarin has antioxidative and antithrombotic effects.

Puerarin may prevent alcohol-induced adipogenesis and osteonecrosis.

Preventive Effects of Puerarin on Alcohol-induced Osteonecrosis.
Clin Orthop Relat Res. 2008 March. Department of Orthopaedic Surgery, 1st Affiliated Hospital, Zhengzhou University, Zhengzhou, China.
Alcohol can induce adipogenesis by bone marrow stromal cells and may cause osteonecrosis of the femoral head. Currently, there are no medications available to prevent alcohol-induced osteonecrosis. Both bone marrow stromal cells (in vitro) and mice (in vivo) were treated either with ethanol or with ethanol and puerarin, with an untreated group serving as a control. IThe data suggest puerarin can inhibit adipogenic differentiation by bone marrow stromal cells both in vitro and in vivo and prevents alcohol-induced osteonecrosis in this model.

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